Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds

ABSTRACT

Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims priority to, and the benefit of, U.S.Provisional Patent Application Ser. No. 61/655,707, filed Jun. 5, 2012,the entire contents of which are incorporated by reference herein.

FIELD OF THE INVENTION

The present disclosure describes methods for the synthesis ofsubstituted aminouracils and xanthine and/or xanthine-related compounds.More specifically, the methods described herein produce selective 1,3disubstituted 6-aminouracils which can be further processed to form awide variety of xanthine and/or xanthine-related compounds.

BACKGROUND OF THE INVENTION

Disubstituted aminouracils may be used to form xanthine andxanthine-related compounds. As illustrated below, one method for thesynthesis of disubstituted aminouracils may include the process ofcondensation of a disubstituted urea (A) with cyanoacetic acid in aceticanhydride (1) followed by base-promoted cyclization (2).

Such a method produces a mixture of two isomeric disubstitutedaminouracils (B) and (C). Thus purification may often be necessary toobtain a single isomer of the disubstituted aminouracil prior toadditional processing to form a xanthine and/or xanthine-relatedcompound. In fact, in some instances, obtaining a single isomer of thedisubstituted aminouracil may not be feasible via condensation, sincethe condensation process may not be sufficiently selective and the ratioamounts of the two isomeric disubstituted aminouracils (B) and (C) maydepend upon the relative size of the substituents and/or functionalgroups of the disubstituted urea (A).

It would be beneficial to provide a selective method for the synthesisof a variety of substituted aminouracils, and specifically disubstitutedaminouracils, in order to selectively place functional groups atspecific positions of the aminouracils prior to the formation ofsubstituted xanthine and/or xanthine-related compounds.

SUMMARY

The present disclosure describes methods for the selective synthesis ofa wide-range of substituted aminouracil compounds and specifically1,3-disubstituted 6-aminouracils, which may be further processed to forma wide-range of xanthine and/or xanthine-related compounds.

In embodiments, a process is described for preparing a compound offormula I:

wherein:

-   -   R¹ and R² are as described hereinbelow,        the process including:        a) reacting a monosubstituted urea of formula II

with ethyl-2-cyanoacetate in the presence of an alkoxide to produce anaminouracil of formula IIIa,

b) reacting the aminouracil of formula IIIa with dimethylformamide-dimethyl acetal to produce a compound of formula IV,

c) reacting the compound of formula IV with either: a R²-boronic acid, afirst metal carbonate and a copper catalyst; a R²-halide, a second metalcarbonate and an aprotic solvent; or, R²—CO—W, a third metal carbonateand an aprotic solvent, to produce a compound of formula V, and,

wherein W is a leaving group,

d) reacting the compound of formula V with an inert solvent and a metalhydroxide to produce the compound of formula I.

In embodiments, a process is described for preparing a xanthine compoundof formula IX:

wherein:

-   -   R¹, R² and R′ are as described hereinbelow        the process including:        a) reacting a monosubstituted urea of formula II

with 3-amino-3-ethoxy-acrylate in the presence of an alkoxide to producean aminouracil of formula IIIb,

b) reacting the aminouracil of formula IIIb with a nitration agent inthe presence of an acid to produce a compound of formula X,

c) reacting the compound of formula X with a reducing agent to produce acompound of formula XI, and,

d) reacting the compound of formula XI with an acylating agent of theformula R′—CO—W′ to produce a compound of formula XII

wherein W′ is a leaving group,

e) reacting the compound of formula XII with a R²-halide, metalcarbonate, and an aprotic solvent to produce a compound of formula XIII,and,

f) reacting the compound of formula XIII with an inert solvent and ametal hydroxide to produce the xanthine compound of formula IX.

DETAILED DESCRIPTION

The present disclosure provides methods for the synthesis of awide-range of selectively substituted aminouracil compounds andspecifically 1,3-disubstituted 6-aminouracils, which may be furtherprocessed to form a wide-range of xanthine and/or xanthine-relatedcompounds. The present methods avoid formation of isomeric mixtures thusproviding for more efficient methods of purification and production.

In embodiments, there is provided a first process for preparing acompound of formula I:

wherein:

-   -   R¹ and R² are independently hydrogen, (C₁-C₈)alkyl,        (C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy,        (C₃-C₈)cycloalkyl, (C₃-C₈)cycloalkyl(C₁-C₈)alkyl-,        (C₄-C₁₀)heterocycle, (C₄-C₁₀)heterocycle(C₁-C₈)alkyl-,        (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)hetero aryl, or        (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-;        the process including:        a) reacting a monosubstituted urea of formula II

with ethyl-2-cyanoacetate in the presence of an alkoxide to produce anaminouracil of formula IIIa,

b) reacting the aminouracil of formula III with dimethylformamide-dimethyl acetal to produce a compound of formula IV,

c) reacting the compound of formula IV with either: a R²-boronic acid, afirst metal carbonate and a copper catalyst; a R²-halide, a second metalcarbonate and an aprotic solvent; or, R²—CO—W, a third metal carbonateand an aprotic solvent, to produce a compound of formula V, and,

wherein W is a leaving group,

d) reacting the compound of formula V with an inert solvent and a metalhydroxide to produce the compound of formula I.

In embodiments, the alkoxide of the first process includes at least onemetal alkoxide, e.g., sodium ethoxide, potassium ethoxide, calciumethoxide, potassium tert-butoxide and sodium tert-butoxide, andcombinations thereof. In embodiments, the metal alkoxide is sodiumethoxide.

In embodiments, step b) of the first process may be exothermic andperformed at a temperature ranging from about 0° C. to about 100° C.,e.g., about 40° C.

In embodiments, the compound of formula IV may be combined with aR²-boronic acid, a first metal carbonate and a copper catalyst toproduce the compound of formula V.

In embodiments, the compound of formula IV may be combined withR²-halide, a second metal carbonate and an aprotic solvent to producethe compound of formula V.

In embodiments, the compound of formula IV may be combined with R²—CO—W,a third metal carbonate and an aprotic solvent to produce the compoundof formula V.

Some non-limiting examples of suitable copper catalysts include copperbromide, copper iodide, copper acetate, copper chloride, coppercarbonate, copper nitrate, copper sulfate, copper hydroxide, coppermethylate, and combinations thereof. In embodiments, the copper catalystis copper acetate.

Some non-limiting examples of first, second and third metal carbonatesinclude sodium carbonate, potassium carbonate, lithium carbonate, cesiumcarbonate, sodium bicarbonate, potassium bicarbonate, lithiumbicarbonate, cesium bicarbonate, and combinations thereof. Inembodiments, the first metal carbonate is sodium carbonate. Inembodiments, the second metal carbonate is potassium carbonate.

Some non-limiting examples of aprotic solvents include dimethylsulfoxide, acetonitrile, acetone, dimethylformamide, ethyl acetate,tetrahydrofuran, dichloromethane, and combinations thereof. Inembodiments, the aprotic solvent of step c) of the first process isdimethylformamide.

In embodiments, the compound of formula IV may be combined with aR²-boronic acid, copper acetate (catalytic) and sodium carbonate in thepresence of an amine ligand to produce the compound of formula V. Inembodiments, the compound of formula IV may be combined with aR²-halide, dimethylformamide and potassium carbonate to produce thecompound of formula V. In embodiments, the compound of formula IV may becombined with a R²—CO—Cl and potassium carbonate to produce the compoundof formula V.

In embodiments, the compound of formula V may combined with at least onemetal hydroxide, e.g., sodium hydroxide, potassium hydroxide, lithiumhydroxide, magnesium hydroxide, and calcium hydroxide, and at least oneinert solvent, e.g., methanol, ethanol, propanol and the like. Inembodiments, the compound of formula V may be combined with sodiumhydroxide and methanol to produce the compound of formula I.

In embodiments, the first process provides conversion of amonosubstituted urea to a disubstituted aminouracil, and specifically a1,3-disubstituted 6-aminouracil, without need for further purification.

In embodiments, the disubstituted aminouracil illustrated in thecompound of formula I may be further processed to produce selectivexanthine and/or xanthine-related compounds which also do not requirefurther purification. Examples of xanthine and/or xanthine-relatedcompounds may be found, e.g., in U.S. Pat. No. 7,342,006 incorporatedherein by reference in its entirety.

In embodiments, the first process may include additional steps:

e) reacting the compound of formula I with a nitration agent to producethe compound of formula VI,

f) reacting the compound of formula VI with a first acylating agent ofthe formula R′—CO—W′ to produce the compound of formula VII, and,

wherein W′ is a leaving group,

g) reacting the compound of formula VII with a reducing agent followedby ring cyclization in an aprotic solvent to produce the xanthinecompound of formula VIII.

In embodiments involving step e) of the first process, the nitrationagent is, e.g., NaNO₂/AcOH, HNO₃/H₂SO₄, N₂O₅/P₂O₅/CCl₄, HONO, EtONO₂,CH₃COONO₂ and NO₂ ⁺CF₃SO₃ ⁻. In embodiments, the nitration agentincludes NaNO₂/AcOH.

In embodiments involving step g) of the first process, the reducingagent is, e.g., hydrogen and palladium on carbon, or sodium dithionite.In embodiments the reducing agent includes sodium dithionite and anaprotic solvent such as dimethyl sulfoxide, acetonitrile, acetone,dimethylformamide, ethyl acetate, tetrahydrofuran, dichloromethane orcombinations thereof. In embodiments involving step g) of the firstprocess, the reducing agent includes sodium dithionite and the aproticsolvent includes dimethyl sulfoxide.

In embodiments, in addition to steps (a)-(e), the first process mayfurther include the additional steps of: h) reacting the compound offormula VI with a reducing agent to produce the compound of formula XIV,

i) reacting the compound of formula XIV with a first acylating agent ofthe formula R′—CO—W′ to produce the compound of formula XV, and,

wherein R′ is as described hereinbelow and W′ is a leaving group,

j) reacting the compound of formula XV with a metal hydroxide to producethe compound of formula VIII.

Optionally, in addition to steps (h)-(j), the first process may furtherinclude the following step:

k) reacting the compound of formula VIII with a second acylating agentof the formula R″—CO—W″ to produce the compound of formula XVI.

wherein R″ is as described hereinbelow, and W″ is a leaving group.

In embodiments, the first and second acylating agents may be the sameand/or different. In embodiments, R′ and R″ may be the same or differentcompounds. In embodiments, W, W′ and W′″ may the same or differentleaving groups. In embodiments, R′ may include a primary or secondaryamine.

In embodiments wherein the first process further includes step (k), R′may be selected from the group consisting of:

In embodiments wherein the first process further includes step (k), R″may be selected from the group consisting of:

In embodiments wherein the first process further includes step (k), R′and R″ may be selected from the following pairs:

In embodiments, there is provided a second process for preparing acompound of formula IX:

wherein:

-   -   R¹ and R² are independently hydrogen, (C₁-C₈)alkyl,        (C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy,        (C₃-C₈)cycloalkyl, (C₃-C₈)cycloalkyl(C₁-C₈)alkyl-,        (C₄-C₁₀)heterocycle, (C₄-C₁₀)heterocycle(C₁-C₈)alkyl-,        (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl, or        (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-;    -   R′ is hydrogen, halogen, substituted or unsubstituted        (C₁-C₈)alkyl, (C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy,        (C₃-C₈)cyclo alkyl, (C₃-C₈)cycloalkyl(C₁-C₈)alkyl-,        (C₄-C₁₀)heterocycle, (C₄-C₁₀)heterocycle(C₁-C₈)alkyl-,        (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)hetero aryl,        (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, or —X(Z¹)_(n)—Z;    -   X is a 5-10 member heteroaryl ring having one nitrogen atom and        optionally interrupted by 1, 2, or 3 non-peroxide oxy (—O—),        thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) or amine —N(R⁹)—        groups;    -   Z is —OR³, —SR³, halo, —S(O)_(m)—NR⁴R⁵, —NR⁴R⁵, or        (C₄-C₁₀)heterocycle wherein the heterocycle is optionally        substituted with 1, 2, 3, or 4 substituents independently        selected from halo, cyano, nitro, —OR^(a), —SR^(a),        (C₁-C₈)alkyl, (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,        R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c),        —C(O)R^(a), —COOR^(a), and —C(O)NR^(b)R^(c);    -   each Z¹ is independently (C₁-C₈)alkyl, (C₂-C₈)alkenyl,        (C₂-C₈)alkynyl, —OR⁶, —SR⁶, halo, R⁶O(C₁-C₈)alkyl,        R⁷R⁸N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR⁷R⁸, R⁷R⁸N(C₁-C₈)alkyl,        —C(O)R⁶, —COOR⁶, and —C(O)NR⁷R⁸;    -   R³ is (C₁-C₈)alkyl, (C₃-C₈)alkenyl, (C₃-C₈)alkynyl,        (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl,        (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —C(O)R⁶, or C(O)NR⁷R⁸;    -   R⁴ and R⁵ are independently hydrogen, (C₁-C₈)alkyl,        (C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy,        (C₃-C₈)cycloalkyl, (C₃-C₈)cycloalkyl(C₁-C₈)alkyl-,        (C₆-C₁₈)polycycloalkyl, (C₆-C₁₈)polycycloalkyl(C₁-C₈)alkyl-,        (C₃-C₁₀)heterocycle, (C₃-C₁₀)heterocycle(C₁-C₈)alkyl —NR⁷R⁸,        (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl,        (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —(C₂-C₄—Y)_(q)—(CH₂)₂₋₄—X¹,        C(O)R⁶, —CO₂R⁶, —C(O)NR⁷R⁸, or —S(O)₂—NR⁷R⁸; or R⁴ and R⁵        together with the atoms to which they are attached form a        saturated or partially unsaturated, mono-, bicyclic- or aromatic        ring having 3, 4, 5, 6, 7, or 8, ring atoms and optionally        comprising 1, 2, 3, or 4 heteroatoms selected from non-peroxide        oxy (—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) and        amine —N(R⁹)— in the ring, wherein the ring is optionally        substituted with 1, 2, 3, or 4 substituents independently        selected from halo, cyano, nitro, —OR^(a), —SR^(a),        (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,        R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c),        —C(O)R^(a), —COOR^(a), and C(O)NR^(b)R^(c);    -   X¹ is —OR⁶, —C(O)R⁶, —CO₂R⁶, or —NR⁷R⁸; and Y is oxy (—O—), thio        (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) and amine —N(R⁹)—;    -   wherein the alkyl, alkenyl, cycloalkyl, alkynyl, aryl,        heterocycle, or heteroaryl groups of R¹, R², R³, R⁴ and R⁵        groups are optionally substituted with one or more substituents        independently selected from halo, cyano, nitro, —OR^(a),        —SR^(a), (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,        R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c),        —C(O)R^(a), —COOR^(a), and —C(O)NR^(b)R^(c);    -   wherein R⁶ is hydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl,        R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, (C₃-C₁₀)heterocycle,        (C₃-C₁₀)heterocycle(C₁-C₈)alkyl-, (C₆-C₁₀)aryl,        (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)hetero aryl,        (C₄-C₁₀)heteroaryl(C₁-C₈)alkyl-; wherein the heterocycle,        heteroaryl or aryl are optionally substituted with 1, 2, 3, or 4        substituents independently selected from halo, cyano, nitro,        —OR^(a), SR^(a), (C₆-C₁₀)aryl —O(C₆-C₁₀)aryl,        hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,        —NR^(b)R^(c), C(O)R^(a), —COOR^(a), and —C(O)NR^(b)R^(c);    -   wherein R⁷, R⁸ and R⁹ are independently hydrogen, (C₁-C₈)alkyl,        R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,        (C₃-C₁₀)hetero cycle, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-,        (C₄-C₁₀)heteroaryl; —COOR^(a), —C(O)R^(a), or —C(O)NR^(b)R^(c)        wherein the heterocycle, heteroaryl or aryl are optionally        substituted with 1, 2, 3, or 4 substituents independently        selected from halo, cyano, nitro, —OR^(a), —SR^(a),        (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,        R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c),        —C(O)R^(a), —COOR^(a), and C(O)NR^(b)R^(c); or R⁷ and R⁸        together with the atoms to which they are attached form a        saturated or partially unsaturated, mono-, bicyclic- or aromatic        ring having 3, 4, 5, 6, 7, or 8, ring atoms optionally ring        having from 4 to eight ring atoms and optionally comprising 1,        2, 3, or 4 heteroatoms selected from non-peroxide oxy (—O—),        thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) or amine        —N(R^(b))— in the ring;    -   R^(a) is hydrogen, or (C₁-C₆)alkyl; R^(b) and R^(c) are each        independently hydrogen, (C₁-C₆)alkyl, (C₁-C₆)alkoxy,        (C₃-C₈)cycloalkyl, (C₁-C₆)alkylthio, (C₆-C₁₀)aryl,        (C₆-C₁₀)aryl(C₁-C₆)alkyl-, heteroaryl, or        heteroaryl(C₁-C₆)alkyl-; or R^(b) and R^(c) together with the        nitrogen to which they are attached, form a pyrrolidyl,        piperidyl, piperazinyl, azepinyl, diazepinyl, morpholinyl, or        thiomorpholinyl ring;    -   where n is 0, 1, 2, 3, 4, 5, 6, 7, or 8; m is 1, or 2; and q is        1, 2, 3, or 4;        the process including:        a) reacting a monosubstituted urea of formula II

with 3-amino-3-ethoxy-acrylate in the presence of an alkoxide to producean aminouracil of formula IIIb,

b) reacting the aminouracil of formula IIIb with a nitration agent toproduce a compound of formula X,

c) reacting the compound of formula X with a reducing agent to produce acompound of formula XI, and,

d) reacting the compound of formula XI with an acylating agent of theformula R′—CO—W′ to produce a compound of formula XII

wherein W′ is a leaving group,

e) reacting the compound of formula XII with a R²-halide, metalcarbonate, and an aprotic solvent to produce a compound of formula XIII,and,

f) reacting the compound of formula XIII with an inert solvent and ametal hydroxide to produce the xanthine compound of formula IX.

In embodiments, the alkoxide of the second process includes at least onemetal alkoxide, e.g., sodium ethoxide, potassium ethoxide, calciumethoxide, potassium tert-butoxide, sodium tert-butoxide, andcombinations thereof. In embodiments, the alkoxide includes sodiumethoxide.

In embodiments, the nitration agent of step b) of the second process mayinclude, e.g., NaNO₂/AcOH, HNO₃/H₂SO₄, N₂O₅/P₂O₅/CCl₄, HONO, EtONO₂,CH₃COONO₂ and NO₂ ⁺CF₃SO₃ ⁻. In embodiments, the nitration agent of thesecond process is NaNO₂/AcOH.

In embodiments, the reducing agent of step c) of the second processincludes, e.g., hydrogen and palladium on carbon, or sodium dithionite.In embodiments, the reducing agent includes sodium dithionite and anaprotic solvent such as dimethyl sulfoxide, acetonitrile, acetone,dimethylformamide, ethyl acetate, tetrahydrofuran, dichloromethane andcombinations thereof. In embodiments involving step c) of the secondprocess, the reducing agent may be sodium dithionite and the aproticsolvent may be dimethyl sulfoxide.

In embodiments, the compound of formula XII may be combined withR²-halide, a metal carbonate and an aprotic solvent to produce thecompound of formula XIII.

Some non-limiting examples of metal carbonates include sodium carbonate,potassium carbonate, lithium carbonate, cesium carbonate, sodiumbicarbonate, potassium bicarbonate, lithium bicarbonate, cesiumbicarbonate, and combinations thereof. In embodiments involving thesecond process, the metal carbonate may be potassium carbonate.

Some non-limiting examples of aprotic solvents include dimethylsulfoxide, acetonitrile, acetone, dimethylformamide, ethyl acetate,tetrahydrofuran, dichloromethane, and combinations thereof. Inembodiments, the aprotic solvent of step e) of the second processincludes dimethylformamide.

In embodiments, the compound of formula XII may be combined with aR²-halide, dimethylformamide and potassium carbonate to produce thecompound of formula XIII.

In embodiments, the compound of formula XIII may be combined with atleast one metal hydroxide, e.g., sodium hydroxide, potassium hydroxide,lithium hydroxide, magnesium hydroxide, calcium hydroxide, andcombinations thereof. In embodiments, the compound of formula XIII mayalso be combined with at least one inert solvent such as methanol,ethanol, propanol and the like. In embodiments, the compound of formulaXIII may be combined with sodium hydroxide and methanol to produce thecompound of formula IX.

In embodiments, the second process provides conversion of amonosubstituted urea to selective xanthine and/or xanthine-relatedcompounds without need for further purification.

Optionally, in addition to steps (a)-(f), the second process may furtherinclude the following step:

g) reacting the compound of formula IX with a second acylating agent ofthe formula R″—CO—W″ to produce the compound of formula XVII.

In embodiments wherein the second process includes step (g), the firstand second acylating agents may be the same and/or different agent. Inembodiments, R′ and R″ may be the same or different compounds. Inembodiments, W, W′ and W″ may the same or different leaving groups. Inembodiments, R′ may include a primary or secondary amine.

In embodiments, wherein the second process further includes step (g), R′may be selected from the group consisting of:

In embodiments wherein the second process further includes step (g), R″may be selected from the group consisting of:

In embodiments wherein the second process further includes step (g), R′and R″ may be selected from the following pairs:

The following definitions are used, unless otherwise described: halo isfluoro, chloro, bromo, or iodo. Alkyl, alkoxy, alkenyl, alkynyl, etc.denote both straight and branched groups; but reference to an individualradical such as “propyl” embraces only the straight chain radical, abranched chain isomer such as “isopropyl” being specifically referredto. When alkyl can be partially unsaturated, the alkyl chain maycomprise one or more (e.g. 1, 2, 3, or 4) double or triple bonds in thechain.

“Aryl” denotes a phenyl radical or an ortho-fused bicyclic carbocyclicradical having about nine to ten ring atoms in which at least one ringis aromatic.

“Arylalkyl” or “(C₆-C₁₀)aryl(C₁-C₈)alkyl-” refer to a group of theformula aryl(C₁-C₈)alkyl-, where aryl and (C₁-C₈)alkyl are as definedherein.

“Heterocycle” encompasses a cyclic radical attached or linked via anitrogen or carbon ring atom of a monocyclic, fused-bicyclic, orbridged-bicyclic, saturated or unsaturated, ring system containing 5-10ring atoms and preferably from 5-6 ring atoms, consisting of carbon andone, two, three or four heteroatoms each selected from the groupconsisting of non-peroxide oxy (—O—), thio (—S—), sulfinyl (—SO—),sulfonyl (—S(O)₂—), amine —N(R⁹)—, or —N═ groups, wherein R⁹ is asdefined herein, and optionally containing 1-3 double bonds (e.g.,—CH═CH— or —CH═N—). Heterocycle includes, for example, tetrahydrofuryl,dihydrofuryl, tetrahydroimidazolyl, azanorbornyl, pyrrolidyl, piperidyl,piperizyl, morpholinyl, azepinyl, 1,3-diazepinyl, 1,3-benzodiazepinyl,1,4-diazepinyl, 1,4-benzodiazepinyl, 1,5-diazepinyl, 1,5-benzodiazepinoand the like.

“Heteroaryl” encompasses a radical attached via a ring atom of amonocyclic aromatic ring containing 5-10 ring atoms, and preferably from5-6 ring atoms, consisting of carbon and one, two, three or fourheteroatoms each selected from the group consisting of non-peroxide oxy(—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) or amine(—N(R⁹)—) groups, wherein R⁹ is as defined herein. Preferred heteroarylgroups include imidazolyl, triazolyl, triazinyl, oxazoyl, isoxazoyl,thiazolyl, isothiazoyl, thiodiazolyl, pyrrolyl, pyrazinyl, tetrazolyl,pyridinyl, pyrimidinyl, indolyl, isoquinolyl, quinolyl and the like.

“Leaving group” encompasses a molecular fragment that departs with apair of electrons in heterolytic bond cleavage. Leaving groups can beanions or neutral molecules. Suitable non-limiting examples of anionicor neutral leaving groups include halides such as Cl⁻, Br⁻, and I⁻,sulfonate esters, such as para-toluenesulfonate (“tosylate”, TsO⁻),water (H₂O), alcohols (—OH), and ammonia.

As is recognized by one of ordinary skill in the art, the ring(s) of thecompounds of the present invention may exist in tautomeric and/orisomeric forms or as tautomers and/or isomers, and thus are alsoincluded within the scope of the invention. For example, isomers arerepresented as the structures (formula IIIa) and (formula IIIb):

By naming or referring to one compound (III), for example, it isunderstood for the purposes of the present application that the isomers(IIIa) and (IIIb) are also intended. Similarly, by referring to compound(IIIa), it is understood for the purposes of the present applicationthat the isomers (III) and (IIIb) are also intended. The same holds truefor references to isomer (IIIb).

“Optional” or “optionally” mean that the subsequently described event orcondition may but need not occur, and that the description includesinstances where the event or condition occurs and instances in which itdoes not. For example, “optionally substituted” means that the namedsubstituent may be present but need not be present, and the descriptionincludes situations where the named substituent is included andsituations where the named substituent is not included.

The terms “include”, “for example”, “such as”, and the like are usedillustratively and are not intended to limit the present invention.

The indefinite articles “a” and “an” mean “at least one” or “one ormore” when used in this application, including the claims, unlessspecifically indicated otherwise.

It will be appreciated by those skilled in the art that compounds of theinvention having a chiral center may exist in and be isolated inoptically active, and racemic forms. Some compounds may exhibitpolymorphism. It is to be understood that the present inventionencompasses any racemic, optically-active, polymorphic, orstereoisomeric form, or mixtures thereof, of a compound of theinvention, which possess the useful properties described herein, itbeing well known in the art how to prepare optically active forms (forexample, by resolution of the racemic form by recrystallizationtechniques, by synthesis from optically-active starting materials, bychiral synthesis, or by chromatographic separation using a chiralstationary phase) and how to determine, for example, anti-tumoractivity, herbicidal activity, or other therapeutic activity using thestandard tests described herein, or using other similar tests which arewell known in the art.

Specific values listed below for radicals, substituents, and ranges, arefor illustration only; they may or may not exclude other defined valuesor other values within defined ranges for the radicals and substituents.

Some non-limiting examples of: (C₁-C₈)alkyl can include methyl, ethyl,n-propyl, isopropyl, n-butyl, iso-butyl, sec-butyl, tert-butyl,n-pentyl, isopentyl, 3-pentyl, n-hexyl, n-heptyl, n-octyl or branched(C₃-C₈)alkyls; (C₂-C₈)alkenyl can include vinyl, 1-propenyl,2-propenyl(allyl), 1-butenyl, 2-butenyl, 3-butenyl, 1-pentenyl,2-pentenyl, 3-pentenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 1-heptenyl,2-heptenyl, 3-heptenyl, 1-octenyl, 2-octenyl, 3-octenyl, 4-octenyl orbranched (C₃-C₈)alkenyls; (C₃-C₈)alkenyl can include, 2-propenyl(allyl),2-butenyl, 3-butenyl, 2-pentenyl, 3-pentenyl, 1-hexenyl, 2-hexenyl,3-hexenyl, 2-heptenyl, 3-heptenyl, 2-octenyl, 3-octenyl, 4-octenyl, orbranched (C₃-C₈)alkenyls; (C₂-C₈)alkynyl can include ethynyl,1-propynyl, 2-propynyl(propargyl), 1-butynyl, 2-butynyl, 3-butynyl,1-pentynyl, 2-pentynyl, 3-pentynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl,1-heptynyl, 2-heptynyl, 3-heptynyl, 1-octynyl, 2-octynyl, 3-octynyl,4-octynyl, or branched (C₃-C₈)alkynyls; (C₃-C₈)alkynyl can include2-propynyl(propargyl), 2-butynyl, 3-butynyl, 1-pentynyl, 2-pentynyl,3-pentynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 1-heptynyl, 2-heptynyl,3-heptynyl, 1-octynyl, 2-octynyl, 3-octynyl, 4-octynyl, or branched(C₃-C₈)alkynyls; (C₁-C₈)alkoxy can include methoxy, ethoxy, n-propoxy,isopropoxy, n-butoxy, iso-butoxy, sec-butoxy, tert-butoxy, pentoxy,3-pentoxy, n-hexyloxy, n-heptyloxy, n-octyloxy, or branched(C₃-C₈)alkoxys; halo(C₁-C₈)alkyl can include iodomethyl, bromomethyl,chloromethyl, fluoromethyl, trifluoromethyl, 2-chloroethyl,2-bromoethyl, 2-fluoroethyl, 3-fluoropropyl, 2,2,2-trifluoroethyl,pentafluoroethyl, or branched halo(C₃-C₈)alkyls; (C₃-C₈)cycloalkyl caninclude cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl orcyclooctyl; (C₃-C₈)cycloalkyl(C₁-C₈)alkyl- can includecyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl,cyclohexylmethyl, 2-cyclopropylethyl, 2-cyclobutylethyl,2-cyclopentylethyl or 2-cyclohexylethyl; (C₆-C₁₀)aryl can includephenyl, indenyl or naphthyl; Heterocycle can include tetrahydrofuryl,dihydrofuryl, tetrahydroimidazolyl, azanorbornyl, pyrrolidyl, piperidyl,piperizyl, morpholinyl, azepinyl, 1,3-diazepinyl, 1,3-benzodiazepinyl,1,4-diazepinyl 1,4-benzodiazepinyl, 1,5-diazepinyl, or1,5-benzodiazepino.

Some non-limiting examples of arylalkyl can include phenylethyl, benzyl,2-phenylpropyl, 3-phenylpropyl, 2-naphthylmethyl or 3-naphthylmethyl;and heteroaryl can include imidazolyl, triazolyl, triazinyl, oxazoyl,isoxazoyl, thiazolyl, isothiazoyl, pyrrolyl, pyrazinyl, tetrazolyl,pyridyl, pyrimidinyl, indolyl, isoquinolyl, quinolyl, or an oxidethereof.

The (C₁-C₈)alkyl groups can be methyl, ethyl, propyl, butyl, pentyl,hexyl, heptyl, and octyl; alkenyl groups are ethenyl, propenyl, butenyl,pentenyl, and hexenyl.

In embodiments, W is a halogen.

In embodiments, W is chloride.

In embodiments, W is an alcohol.

In embodiments, W′ is a halogen.

In embodiments, W′ is chloride.

In embodiments, W′ is an alcohol.

In embodiments, W″ is a halogen.

In embodiments, W″ is chloride.

In embodiments, W″ is an alcohol.

In embodiments, R¹ is hydrogen, (C₁-C₄)alkyl, (C₃-C₄)alkenyl,(C₃-C₄)alkynyl, phenyl, or phenyl(C₁-C₄)alkyl.

In embodiments, R¹ is (C₃-C₆)cycloalkyl or(C₃-C₆)cycloalkyl(C₁-C₄)alkyl.

In embodiments, R¹ includes cyclopropyl or cyclopropylmethyl.

In embodiments, R¹ is hydrogen, methyl, ethyl, allyl, propargyl,i-propyl, n-propyl, n-butyl, i-butyl, phenyl, phenethyl, or benzyl.

In embodiments, R¹ is hydrogen, methyl, ethyl, allyl, propargyl,i-propyl, n-propyl, or (methoxyphenyl)ethyl.

In embodiments, R¹ includes propyl or cyclopropyl.

In embodiments, R² is hydrogen, (C₁-C₄)alkyl, (C₃-C₄)alkenyl,(C₃-C₄)alkynyl, phenyl, or phenyl(C₁-C₄)alkyl.

In embodiments, R² is (C₃-C₆)cycloalkyl and(C₃-C₆)cycloalkyl(C₁-C₄)alkyl-.

In embodiments, R² is cyclopropyl or cyclopropylmethyl.

In embodiments, R² is hydrogen, methyl, ethyl, allyl, propargyl,i-propyl, n-propyl, n-butyl, i-butyl, phenyl, phenethyl, or benzyl.

In embodiments, R² is hydrogen, methyl, ethyl, allyl, propargyl,i-propyl, n-propyl, or (methoxyphenyl)ethyl.

In embodiments, R² is propyl or cyclopropyl.

In embodiments, R′ is (C₃-C₆)cycloalkyl and(C₃-C₆)cycloalkyl(C₁-C₄)alkyl-.

In embodiments, R′ is cyclopropyl or cyclopropylmethyl.

In embodiments, R′ is hydrogen, (C₁-C₄)alkyl, (C₃-C₄)alkenyl,(C₃-C₄)alkynyl, phenyl, or phenyl(C₁-C₄)alkyl.

In embodiments, R′ is X(Z¹)_(n)—Z.

In embodiments, X is imidazolyl, triazolyl, triazinyl, oxazoyl,isoxazoyl, thiazolyl, isothiazoyl, thiodiazolyl, pyrrolyl, pyrazinyl,tetrazolyl, pyridinyl, pyrimidinyl, indolyl, isoquinolyl, or quinolyl,each optionally substituted with 1, 2, or 3 substituents independentlyselected from halo, cyano, nitro, (C₁-C₈)alkyl, —OR^(a), SR^(a),(C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a),—COOR^(a), and C(O)NR^(b)R^(c).

In embodiments, X is 2-pyridinyl, 3-pyridinyl, or 4-pyridinyl, eachoptionally substituted with 1, 2, or 3 substituents independentlyselected from halo, cyano, nitro, (C₁-C₈)alkyl, OR^(a), SR^(a),(C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a),—COOR^(a), and —C(O)NR^(b)R^(c).

In embodiments, Z is —OH, —O(C₁-C₄)alkyl, —O(C₆-C₁₀)aryl,—O(C₆-C₁₀)aryl(C₁-C₄)alkyl, —NR⁴R⁵, F, Cl, Br, or I.

In embodiments, Z is —NR⁴R⁵.

In embodiments, X(Z¹)_(n)—Z includes

In embodiments, the processes described herein may be used to formxanthine and/or xanthine-related compounds, some non-limiting examplesinclude:

In embodiments the process described herein may prepare compounds of theformulas XVI or XVII

wherein:

-   -   R¹ and R² are independently hydrogen, (C₁-C₈)alkyl,        (C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy,        (C₃-C₈)cycloalkyl, (C₃-C₈)cycloalkyl(C₁-C₈)alkyl-,        (C₄-C₁₀)heterocycle, (C₄-C₁₀)heterocycle(C₁-C₈)alkyl-,        (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl, or        (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-;    -   R′ and R″ are independently hydrogen, halogen, substituted or        unsubstituted (C₁-C₈)alkyl, (C₃-C₈)alkenyl, (C₃-C₈)alkynyl,        (C₁-C₈)alkoxy, (C₃-C₈)cyclo alkyl,        (C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₄-C₁₀)heterocycle,        (C₄-C₁₀)heterocycle(C₁-C₈)alkyl-, (C₆-C₁₀aryl,        (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl,        (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, or —X(Z¹)_(n)—Z;    -   X is a 5-10 member heteroaryl ring having one nitrogen atom and        optionally interrupted by 1, 2, or 3 non-peroxide oxy (—O—),        thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) or amine —N(R⁹)—        groups;    -   Z is —OR³, —SR³, halo, —S(O)_(m)—NR⁴R⁵, —NR⁴R⁵, or        (C₄-C₁₀)heterocycle wherein the heterocycle is optionally        substituted with 1, 2, 3, or 4 substituents independently        selected from halo, cyano, nitro, —OR^(a), —SR^(a),        (C₁-C₈)alkyl, (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,        R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c),        —C(O)R^(a), —COOR^(a), and —C(O)NR^(b)R^(c);    -   each Z¹ is independently (C₁-C₈)alkyl, (C₂-C₈)alkenyl,        (C₂-C₈)alkynyl, —OR⁶, —SR⁶, halo, R⁶⁰ (C₁-C₈)alkyl,        R⁷R⁸N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR⁷R⁸, R⁷R⁸N(C₁-C₈)alkyl,        —C(O)R⁶, —COOR⁶, and —C(O)NR⁷R⁸;    -   R³ is (C₁-C₈)alkyl, (C₃-C₈)alkenyl, (C₃-C₈)alkynyl,        (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl,        (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —C(O)R⁶, or —C(O)NR⁷R⁸;    -   R⁴ and R⁵ are independently hydrogen, (C₁-C₈)alkyl,        (C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy,        (C₃-C₈)cycloalkyl, (C₃-C₈)cycloalkyl(C₁-C₈)alkyl-,        (C₆-C₁₈)polycycloalkyl, (C₆-C₁₈)polycycloalkyl(C₁-C₈)alkyl-,        (C₃-C₁₀)heterocycle, (C₃-C₁₀)heterocycle(C₁-C₈)alkyl —NR⁷R⁸,        (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl,        (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —(C₂-C₄—Y)_(q)—(CH₂)₂₋₄—X¹,        —C(O)R⁶, —CO₂R⁶, —C(O)NR⁷R⁸, or —S(O)₂—NR⁷R⁸; or R⁴ and R⁵        together with the atoms to which they are attached form a        saturated or partially unsaturated, mono-, bicyclic- or aromatic        ring having 3, 4, 5, 6, 7, or 8, ring atoms and optionally        comprising 1, 2, 3, or 4 heteroatoms selected from non-peroxide        oxy (—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) and        amine —N(R⁹)— in the ring, wherein the ring is optionally        substituted with 1, 2, 3, or 4 substituents independently        selected from halo, cyano, nitro, —OR^(a), —SR^(a),        (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,        R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c),        —C(O)R^(a), —COOR^(a), and —C(O)NR^(b)R^(c);    -   X¹ is —OR⁶, —C(O)R⁶, —CO₂R⁶, or —NR⁷R⁸; and Y is oxy (—O—), thio        (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) and amine —N(R⁹)—;    -   wherein the alkyl, alkenyl, cycloalkyl, alkynyl, aryl,        heterocycle, or heteroaryl groups of R¹, R², R³, R⁴ and R⁵        groups are optionally substituted with one or more substituents        independently selected from halo, cyano, nitro, —OR^(a),        —SR^(a), (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,        R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c),        —C(O)R^(a), —COOR^(a), and —C(O)NR^(b)R^(c);    -   wherein R⁶ is hydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl,        R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, (C₃-C₁₀)heterocycle,        (C₃-C₁₀)heterocycle(C₁-C₈)alkyl-, (C₆-C₁₀)aryl,        (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)hetero aryl,        (C₄-C₁₀)heteroaryl(C₁-C₈)alkyl-; wherein the heterocycle,        heteroaryl or aryl are optionally substituted with 1, 2, 3, or 4        substituents independently selected from halo, cyano, nitro,        —OR^(a), SR^(a), (C₆-C₁₀)aryl —O(C₆-C₁₀)aryl,        hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,        —NR^(b)R^(c), —C(O)R^(a), —COOR^(a), and —C(O)NR^(b)R^(c);    -   wherein R⁷, R⁸ and R⁹ are independently hydrogen, (C₁-C₈)alkyl,        R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,        (C₃-C₁₀)hetero cycle, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-,        (C₄-C₁₀)heteroaryl; —COOR^(a), —C(O)R^(a), or —C(O)NR^(b)R^(c)        wherein the heterocycle, heteroaryl or aryl are optionally        substituted with 1, 2, 3, or 4 substituents independently        selected from halo, cyano, nitro, —OR^(a), —SR^(a),        (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,        R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c),        —C(O)R^(a), —COOR^(a), and C(O)NR^(b)R^(c); or R⁷ and R⁸        together with the atoms to which they are attached form a        saturated or partially unsaturated, mono-, bicyclic- or aromatic        ring having 3, 4, 5, 6, 7, or 8, ring atoms optionally ring        having from 4 to eight ring atoms and optionally comprising 1,        2, 3, or 4 heteroatoms selected from non-peroxide oxy (—O—),        thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) or amine        —N(R^(b))— in the ring;    -   R^(a) is hydrogen, or (C₁-C₆)alkyl; R^(b) and R^(c) are each        independently hydrogen, (C₁-C₆)alkyl, (C₁-C₆)alkoxy,        (C₃-C₈)cycloalkyl, (C₁-C₆)alkylthio, (C₆-C₁₀)aryl,        (C₆-C₁₀)aryl(C₁-C₆)alkyl-, heteroaryl, or        heteroaryl(C₁-C₆)alkyl-; or R^(b) and R^(c) together with the        nitrogen to which they are attached, form a pyrrolidyl,        piperidyl, piperazinyl, azepinyl, diazepinyl, morpholinyl, or        thiomorpholinyl ring;    -   where n is 0, 1, 2, 3, 4, 5, 6, 7, or 8; m is 1, or 2; and q is        1, 2, 3, or 4Turning now to Reaction Schemes A and B provided        below, Reaction Scheme A illustrates a general synthetic scheme        for the preparation of a 1,3-disubstituted 6-aminouracil and the        compound of formula I wherein R₁ is propyl and R₂ is        cyclopropyl. Reaction Scheme B illustrates a general synthetic        scheme for the preparation of a xanthine and/or xanthine-related        compound of the compound of formula IX wherein R₁ is cyclopropyl        and R₂ is propyl.

In step 1 of Reaction Scheme A, a 1-substituted 6-aminouracil may beinitially produced by the condensation of a monosubstituted urea, i.e.,1-propylurea, with ethyl-2-cyanoacetate in the presence of sodiumethoxide. The sodium ethoxide may be dissolved in a solvent, such asanhydrous ethanol. The condensation reaction may be performed at about50° C. for about 24 hours or until deemed complete. The residue wasdissolved in water and the pH adjusted to about 7 using HCl. The productwas collected by filtration, washed with water and dried under vacuum.

In step 2 of Reaction Scheme A, protection of the 1-substituted6-aminouracil may be performed by suspending the aminouracil indimethylformamide (DMF) and reacting the suspended aminouracil withDMF-DMA (dimethyl formamide-dimethyl acetal). The protection reactionmay occur at a temperature of about 40° C. for about 4 hours or untildeemed complete and allowed to cool to about 0° C. for an hour. Theprotected 1-substituted 6-aminouracil was collected by filtration,washed with MTBE and dried under vacuum overnight.

In step 3 of Reaction Scheme A, alkylation of the 3-position of theprotected 1-substituted 6-aminouracil may be performed by reacting theprotected aminouracil with cyclopropyl boronic acid, sodium carbonate,copper acetate and bipyridine. Dimethyl carbonate may also be added. Thereaction may be performed at about 75° C. and stirred for about 3 hoursor until deemed complete. The result may be allowed to cool to aboutroom temperature before being filtered and washed with ethyl acetate.The filtrate may be extracted with a NH₄Cl solution and washed againwith ethyl acetate. The result may be washed, dried and concentratedunder pressure to provide a product capable of being combined with MTBEand heated for about 30 minutes. The product may be allowed to cool toabout 0° C. for an hour. The protected 1,3-disubstituted 6-aminouracilwas collected by filtration and washed with MTBE.

In step 4 of Reaction Scheme A, deprotection of the protected1,3-disubstituted 6-aminouracil may occur by reacting the protected1,3-disubstituted 6-aminouracil with methanol and sodium hydroxide forabout 15 hours under stirring until the methanol is evaporated. Thereaction may be allowed to cool to about 0° C. for an hour with theaddition of water. The 1,3-disubstituted 6-aminouracil was collected byfiltration, rinsed with water and dried under vacuum at about 40° C.overnight.

In step 1 of Reaction Scheme B, a 3-substituted 6-aminouracil may beinitially produced by the condensation of a monosubstituted urea, i.e.,cyclopropylurea, with ethyl-3-amino-3-ethoxyacetate and ethanol. Thecondensation reaction may be performed at about 75° C. for about 2 hoursbefore the addition of sodium ethoxide and allowed to proceed for aboutanother hour. The ethanol may be evaporated and water added the pHadjusted to about 4-5 using HCl. The product was collected byfiltration, washed with water and dried under vacuum overnight.

In step 2 of Reaction Scheme B, nitration of the 3-substituted6-aminouracil may occur by combining the 3-substituted 6-aminouracilwith acetic acid and adding small portions of sodium nitrite over aperiod of minutes, preferably 10 minutes and stirring. The nitrated3-substituted 6-aminouracil was collected by filtration, and washed withwater.

In step 3 of Reaction Scheme B, a reduction reaction may be performed onthe nitrated 3-substituted 6-aminouracil by suspending the nitrated3-substituted 6-aminouracil in methanol and adding PtO₂ and a stream ofH₂ for about 2 hours. Dichloromethane may be added to dissolve theproduct and the Pt may be filtered and the methanol removed to yield a3-substituted 5,6-diaminouracil.

In step 4 of Reaction Scheme B, acylation at the 5-position of the3-substituted 5,6-diaminouracil may occur by reacting the 3-substituted5,6-diaminouracil with acyl reagent of a formula R′—CO—W under properconditions. The 3-substituted 5-acylated 6-aminouracil may be isolatedby filtration and collected using techniques known to those skilled inthe art.

In step 5 of Reaction Scheme B, the 1-position of the 3-substituted5-acylated 6-aminouracil may be alkylated by reacting the 3-substituted5-acylated 6-aminouracil with an alkyl halide, potassium carbonate undermild conditions in DMF. The 1,3-disubstituted, 5-acylated, 6-aminouracilmay be isolated by filtration and collected using techniques known tothose skilled in the art.

In step 6 of Reaction Scheme B, the 1,3-disubstituted, 5-acylated,6-aminouracil may be cyclized to produce a xanthine compound. The1,3-disubstituted, 5-acylated, 6-aminouracil may be cyclized by reactingthe 1,3-disubstituted, 5-acylated, 6-aminouracil with a base such assodium hydroxide and methanol. The resulting xanthine compound may beisolated, filtered and collected using techniques known to those skilledin the art.

Example 1

6-Amino-1-propyl-1H-pyrimidine-2,4-dione

Sodium ethoxide (19.99 g, 293.72 mmol, 2 eq) was dissolved in anhydrousethanol (210 ml) at 50° C. To the solution was added ethyl2-cyanoacetate (15.67 ml, 146.86 mmol, 1 eq) then 1-propylurea (15 g,146.86 mmol, 1 eq), and the mixture was stirred at reflux for 24 hours.The solvent was evaporated under reduced pressure, and the residue wasdissolved in water (70 ml). The pH of the solution was adjusted to ˜7 byusing concentrated HCl. The light yellow solid formed was collected byfiltration, washed with water, and dried under vacuum to afford 23.82 gof the desired product (96% yield): The desired isomer was determinedvia 2D-NMR; ¹H NMR (400 MHz, DMSO-d₆) δ 10.3 (1H), 6.79 (2H), 4.52 (1H),3.68-3.70 (2H), 1.50 (2H), 0.85 (3H); m/z (ES+) 170.18

Example 2

N′-(2,6-Dioxo-3-propyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-N,N-dimethyl-formadidine

To a suspension of 6-amino uracil (15 g, 88.66 mmol, 1 eq) in DMF (125ml) was added DMF-DMA (12.96 ml, 97.53 mmol, 1.1 eq). The mixture washeated at 40° C. for 4 hours. The reaction flask is cooled to 0° C. for1 hour then collected by filtration and washed with MTBE (50 ml) toafford 18.07 g (91%) after dried under vacuum at 40° C. overnight: ¹HNMR (400 MHz, DMSO-d₆) δ10.58 (1H), 8.05 (1H), 4.96 (1H), 3.8-3.82 (2H),3.10 (3H), 2.98 (3H), 1.54 (2H), 0.83 (3H); m/z (ES+) 225.26

Example 3

N′-(1-Cyclopropyl-2,6-Dioxo-3-propyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-N,N-dimethyl-formamidine

In a 500 ml 3-necked round bottom flask is charged with protected uracil(15.00 g, 66.89 mmol, 1 eq), cyclopropyl boronic acid (6.90 g, 80.27mmol, 1.2 eq), sodium carbonate (14.18 g, 133.78 mmol, 2 eq), Cu(OAc)₂(2.43 g, 13.38 mmol, 0.2 eq), and bipyridine (2.09 g, 13.38 mmol, 0.2eq). Dimethyl carbonate (150 ml) was added. The mixture was warmed to75° C. and stirred for 3 hours under air (in house air was used;filtered through calcium sulfate cylinder). The resulting mixture wascooled to mom temperature, filtered through Celite pad, and washed withEtOAc (100 ml). The filtrate was extracted with saturated aqueous NH₄Clsolution (300 ml); washed the aqueous layer with EtOAc (2×100 ml). Thecombined organic layers were washed with brine, dried, and concentratedunder reduce pressure. To the crude product was added MTBE (150 ml) thenheated to reflux for 30 minutes before slowly cooled to 0° C. for 1 hr;product was collected by filtration and washed with MTBE (100 ml) togive product in good yield 14.66 g (83%): ¹H NMR (400 MHz, DMSO-d₆) δ8.05 (1H), 5.05 (1H), 3.85 (2H), 3.1 (3H), 2.97 (3H), 2.50 (1H), 1.58(2H), 0.92 (2H), 0.83 (3H), 0.62 (2H); m/z (ES+) 265.33

Example 4

6-Amino-3-cyclopropyl-1-propyl-1H-pyrimidine-2,4-dione

In a 500 ml round bottom flask is charged withN,N-dimethylaminomethylene uracil (15.0 g, 56.75 mmol, 1 eq), followedby methanol (100 ml), and 2N NaOH (56.75 nil, 2 eq). After 15 hours ofstirring, methanol was evaporated then cooled to 0° C. for 1 hour withan addition of water (25 nil). Product was filtered, rinsed with coldwater, dried under vacuum at 40° C. overnight to give 10.91 g (92%): ¹HNMR (400 MHz, DMSO-d₆) δ 6.72 (2H), 4.59 (1H), 3.70 (2H), 2.45 (1H),1.50 (2H), 0.85 (5H), 0.59 (2H); m/z (ES+) 210.25

Example 5

6-Amino-3-cyclopropyl-5-nitroso-1-propyl-1H-pyrimidine-2,4-dione

To a solution of 1-propyl-3-cyclopropyl-6-aminouracils (10 g, 47.85mmol, 1 eq) in AcOH (31.14 ml, 550.28 mmol, 11.5 eq) and water (9 ml)was added NaNO₂ solution (3.71 g, 52.64 mmol, 1.1 eq) in 20 ml of water,and the mixture was stirred at room temperature for 2 hours. Purplesolid formed was collected by filtration and washed with cold water toafford compound indicated (8.44 g, 74%) after vacuum dried over night:¹H NMR (400 MHz, DMSO-d₆) δ 13.25 (1H), 9.08 (1H), 3.75 (2H), 2.65 (1H),1.50 (2H), 1.02 (2H), 0.86 (3H), 0.75 (2H); m/z (ES+) 239.25

Example 6

6-Chloro-N-(1-cyclopropyl-5-nitroso-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-nicotinamide

To a solution of nitroso uracil (5.5 g, 23.1 mmol, 1 eq) in EtOAc (110ml) was added triethylamine (4.84 ml, 34.65 mmol, 1.5 eq) followed by6-chloronicotinoyl chloride (4.06 g, 23.1 mmol, 1 eq). The mixture wasstirred under nitrogen for two hrs. After that time, the mixture wasquenched with water and extracted with EtOAc (2×). The organic phase wasdried with anhydrous Na₂SO₄, filtered and the solvent was removed underreduced pressure, obtaining (8.2 g, 94%, m/z (ES+) 378.8), which wasused in the following step without purifying.

Example 7

8-(6-Chloro-pyridin-3-yl)-1-cyclopropyl-3-propyl-3,7-dihydro-purine-2,6-dione

To a solution of6-Chloro-N-(1-cyclopropyl-5-nitroso-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-nicotinamide(8.2 g, 21.71 mmol, 1 eq) in 60 ml of DMSO was added Na₂S₂O₄ (15.11 g,86.84 mmol, 4 eq). The mixture was stirred at 90° C. for 3 hours. Themixture was quenched with water (50 ml). The resulting precipitate wasobtained by filtration and washed with water to give the desired product(5.78 g, 77%) after vacuum dried overnight at 40° C.: ¹H NMR (400 MHz,DMSO-d₆) δ 14.1 (1H), 9.08 (1H), 8.48 (1H), 7.7 (1H), 4.00 (2H), 2.62(1H), 1.78 (2H), 1.14 (2H), 0.92 (3H), 0.75 (2H); m/z (ES+) 346.79

Example 8

5,6-Diamino-3-cyclopropyl-1-propyl-1,1-pyrimidine-2,4-dione

A solution of sodium dithionite (13.15 g, 75.6 mmol, 6 eq) in H₂O (50ml) was added to a suspension of6-Amino-3-cyclopropyl-5-nitroso-1-propyl-1H-pyrimidine-2,4-dione (3 g,12.6 mmol) in MeOH (50 ml) at room temperature. After stirring for 30minutes, the precipitate went from purple to white. The reaction mixturewas stirred for an additional 2 hours before methanol was evaporateunder reduced pressure. The mixture was extracted with EtOAc (2×). Theorganic phase was dried with anhydrous Na₂SO₄, filtered and the solventwas removed under reduced pressure, obtaining (2.49 g, 88%, m/z (ES+)225.46), which was used in the following step without purifying.

Example 9

6-(2-Methoxy-ethylamino)-nicotinic acid ethyl ester

500 ml 3-necked round bottom flask is charged with pyridine chloride(27.69 g, 150 mmol), DMF (200 ml), K₂CO₃ (31.05 g, 225 mmol, 1.5 eq),methoxy ethylene amine (16.9 ml, 195 mmol, 1.3 eq) and heated whilestirring at 90-95° C. Monitor by HPLC for every 2 hours. Reactioncompleted after 10 hours. Solid was filtered, washed with toluene (70ml). The filtrate was extracted with water and back extracted withtoluene. The combined organic layers were washed with brine, dried, andconcentrated under reduce pressure. Heptane was added to the crudeproduct and stirred for 30 min at 0° C. before filtered and dried togive 22.71 g (67.6%) of clean product: ¹H NMR (400 MHz, DMSO-d₆) δ 8.55(1H), 7.78 (1H), 7.48 (1H), 6.55 (1H), 4.2 (2H), 3.48 (4H), 3.25 (3H),1.25 (3H); m/z (ES+) 224.26

Example 10

6-[(2,2-Dimethyl propionyl)-(2-methoxy-ethyl)-amino]-nicotinic acid

TEA was added to a solution of 6-(2-Methoxy-ethylamino)-nicotinic acidethyl ester (3.36 g, 15 mmol) in DCM (55 ml) and cooled to 0° C. PivCl(1.94 ml, 15.75 mmol, 1.05 eq) in DCM (3 ml) was slowly added and thereaction mixture was stirred for 30 min at 0° C. then 2 hours at roomtemperature. The reaction mixture was poured into 50 ml of water, andaqueous layer was extracted with DCM (3×30 ml). Organic layers werewashed with NaHCO₃ sat, water and brine, dried over anhydrous Na₂SO₄,filtered and the solvent was concentrated under reduced pressure todryness, obtaining 4.62 g of oily product, which was used in thefollowing step without purifying.

LiOH (1.89 g, 45 mmol, 3 eq) was added to a stirred solution of ester(4.62 g, 15 mmol) in THF/MeOH/Water (30 ml, 15 ml, 7.5 ml) and resultingmixture was stirred at room temperature for 45 min and monitored viaHPLC. Reaction mixture was evaporated to dryness and redissolved therest in 75 ml of water; the solution was acidified to pH 1 with 10% HCl,filtered solid and washed with water. Product was dried in vacuum at 50°C. overnight to obtain 3.52 g (83.2%) of white solid. ¹H NMR (400 MHz,DMSO-d₆) δ 13.4 (1H), 8.89 (1H), 8.32 (1H), 7.5 (1H), 3.8 (2H), 3.45(2H), 3.18 (3H), 0.98 (9H); m/z (ES+) 280.33

Example 11

1-Cyclopropyl-8-[6-(2-methoxy-ethylamino)-pyridin-3-yl]-3-propyl-3,7-dihydro-purine-2,6-dione

Oxalyl chloride (0.98 ml, 11.25 mmol, 1.05 eq) was added dropwise to astirred solution of6-[(2,2-Dimethyl-propionyl)-(2-methoxy-ethyl)-amino]-nicotinic acid (3g, 10.71 mmol) in DCM (30 Ml) at 0° C. followed by one drop of DMF.Stirred at that temperature for 30 min before the addition of5,6-Diamino-3-cyclopropyl-1-propyl-1H-pyrimidine-2,4-dione (2.4 g, 10.71mmol, 1 eq) and followed by pyridine (0.866 ml, 10.71 mmol, 1 eq). Thereaction mixture was allowed to warm to room temperature for 3 hr thenthe mixture was evaporated to dryness and redissolved in 30 ml of 4NNaOH. The reaction mixture was heated to reflux for a total of 5 hours.After cooling to room temperature, the pH adjusted with aqueoushydrochloric acid to 7-8. Water was evaporated to half volume thenethanol was added at 0° C. and stirred overnight (15 hr). The reactionmixture is filtered and the solid was washed with water and thenethanol. The product is then dried at 50° C. to provide 3.41 g (83%). ¹HNMR (400 MHz, DMSO-d₆) δ 13.68 (1H), 8.7 (1H), 8.0 (1H), 7.15 (1H), 6.6(1H), 3.95 (2H), 3.48 (4H), 3.26 (3H), 2.6 (1H), 1.7 (2H), 1.05 (2H),0.9 (3H), 0.7 (2H); m/z (ES+) 385.44

Example 12

N-[5-(1-Cyclopropyl-2,6-dioxo-3-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-pyridin-2-yl]-6-fluoro-N-(2-methoxy-ethyl)-nicotinamide

1-Cyclopropyl-8-[6-(2-methoxy-ethylamino)-pyridin-3-yl]-3-propyl-3,7-dihydro-purine-2,6-dione(2 g, 5.20 mmol) is charged to a reaction flask, followed by anhydroustetrahydrofuran (25 ml) and N,N-diisopropylethylamine (5 eq).6-fluoronicotinoyl chloride (1.16 g, 7.28 mmol, 1.4 eq) is added and themixture is heated to 60° C. It is held for 12 hr and sampled forreaction completion via HPLC: When the reaction is complete, it iscooled to room temperature and water is added then filtered. Thefiltrate is concentrated then the resulting product is triturated withmethanol at 60° C. then cooled to room temperature and filtered. Thecrude product was again triturated with methanol, filtered and againwashed with methanol. The product is then dried at 50° C. to provide2.41 g (91%). ¹H NMR (400 MHz, DMSO-d₆) δ 13.95 (1H), 8.9 (1H), 8.32(1H), 8.15 (1H), 7.89 (1H), 7.39 (1H), 7.15 (1H), 4.2 (2H), 3.95 (2H),3.6 (2H), 3.18 (3H), 2.6 (1H), 1.7 (2H), 1.05 (2H), 0.9 (3H), 0.7 (2H);m/z (ES+) 508.53

Example 13

6-Amino-3-cyclopropyl-1H-pyrimidine-2,4-dione

A solution of cyclopropyl urea (10 g, 100 mmol, 1 eq) and ethyl3-amino-3-ethoxy-acrylate HCl (19.55 g, 100 mmol, 1 eq) in Ethanol (125ml) was heated at 75° C. for 2 hours. To this solution was added 2equivalents of NaOEt then heated for an additional one hour. Solvent wasevaporated, water (50 ml) was added then acidified via concentrated HClto pH of 4-5. The resulting precipitate was obtained by filtration andwashed with cold water to give the desired product (9.35 g, 56%) aftervacuum dried overnight at 40° C.: The desired isomer was determined via2D-NMR; ¹H NMR (400 MHz, DMSO-d₆) δ 10.18 (1H), 6.10 (2H), 4.44 (1H),2.38 (1H), 0.85 (2H), 0.62 (2H); m/z (ES+) 168.17

Example 14

6-Amino-3-cyclopropyl-5-nitrosouracil

To a solution of 6-Amino-3-cyclopropyl-1H-pyrimidine-2,4-dione (5.0 g,29.9 mmol, 1 eq) in 50% aq AcOH (10 ml) was added NaNO₂ (4.13 g, 59.8mmol, 2 eq) in small portions over a period of 10 min. The mixture wasstirred for 1 hr. The purple precipitate was collected by filtration andwashed with cold water to give 4.75 g, 81%, m/z (ES+) 197.17), which wasused in the following step.

Example 15

8-(6-Chloro-pyridin-3-yl)-1-cyclopropyl-3-propyl-3,7-dihydro-purine-2,6-dione

6-Amino-3-cyclopropyl-5-nitrosouracrl (4.75 g, 24.21 mmol) was suspendedin MeOH (100 ml). Pt0₂ (0.08 g) was added and a stream of H₂ was passedthrough the suspension. After 2 hr the colored suspension had turnedwhite. CH₂Cl₂ (200 ml) was added to dissolve the product. Pt wasfiltered off and the solvent removed in vacuo to yield the labilediaminouracil (4.29 g, 98%)

To the crude diamine (4.29 g, 23.72 mmol) in EtOAc (50 ml) was added6-chloronicotinoyl chloride (4.59 g, 26.09 mmol, 1.1 eq) and pyridine(35.58 mmol, 1.5 eq). The reaction mixture was stirred for 2 hours.Quenched with water and extracted with EtOAc. The organic phase wasdried with anhydrous Na₂SO₄, filtered and the solvent was removed underreduced pressure. To this crude acyl adduct was added 2N NaOH (2.5 eq,30 ml) then drop wise of di-n-propyl sulfate (4.3 g, 23.72 mmol, 1 eq).The mixture was heated at 50° C. for 1 hr. To this reaction mixture wasadded methanol (20 ml) and two more equivalents of 2N NaOH. The mixturewas heated at reflux for 3 hours before cooled and acidified with HCl topH ˜7. The resulting precipitate was obtained by filtration and washedwith water to give the desired product (5.89 g, 72%) after vacuum driedovernight at 40° C.: ¹H NMR (400 MHz, DMSO-d₆) δ 14.1 (1H), 9.08 (1H),8.48 (1H), 7.7 (1H), 4.00 (2H), 2.62 (1H), 1.78 (2H), 1.14 (2H), 0.92(3H), 0.75 (2H); m/z (ES+) 346.79

The subject matter herein has been described with reference to variousspecific and preferred embodiments and techniques. However, it should beunderstood that that those skilled in the art may envision thatvariations and modifications may be made while remaining within thespirit and scope of the claims. It should also be understood that thevarious examples set forth herein have been included for purposes ofillustration and should not be construed as limitations. Accordingly,the disclosure is not to be limited by what has been particularly shownand described, except as indicated by the appended claims.

What is claimed is:
 1. A process for preparing a compound of formula I:

wherein: R¹ and R² are independently hydrogen, (C₁-C₈)alkyl,(C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy, (C₃-C₈)cycloalkyl,(C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₄-C₁₀)heterocycle,(C₄-C₁₀)heterocycle(C₁-C₈)alkyl-, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)hetero aryl, or(C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-; the process comprising: a) reacting amonosubstituted urea of formula II

 with ethyl-2-cyanoacetate in the presence of an alkoxide to produce anaminouracil of formula IIIa,

b) reacting the aminouracil of formula Ma with dimethylformamide-dimethyl acetal to produce a compound of formula IV,

c) reacting the compound of formula IV with either: a R²-boronic acid, afirst metal carbonate and a copper catalyst; a R²-halide, a second metalcarbonate and an aprotic solvent; or, R²—CO—W, a third metal carbonateand an aprotic solvent, to produce a compound of formula V, and,

wherein W is a leaving group d) reacting the compound of formula V withan inert solvent and a metal hydroxide to produce the compound offormula I.
 2. The process according to claim 1, wherein the alkoxide isa metal alkoxide selected from the group consisting of potassiumtert-butoxide, sodium ethoxide, potassium ethoxide, calcium ethoxide,sodium tert-butoxide and combinations thereof.
 3. The process accordingto claim 2, wherein the metal alkoxide is sodium ethoxide.
 4. Theprocess according to claim 1, wherein step b) is performed at atemperature of about 0° C. to about 100° C.
 5. The process according toclaim 4, wherein step b) is performed at a temperature of about 40° C.6. The process according to claim 1, wherein step b) further includes anorganic solvent selected from the group consisting of dimethylformamide,toluene, xylene and combinations thereof.
 7. The process according toclaim 1, wherein the copper catalyst is selected from the groupconsisting of copper bromide, copper iodide, copper acetate, copperchloride, copper carbonate, copper nitrate, copper sulfate, copperhydroxide, copper methylate and combinations thereof.
 8. The processaccording to claim 7, wherein the copper catalyst comprises copperacetate.
 9. The process according to claim 1, wherein the first metalcarbonate is selected from the group consisting of sodium carbonate,potassium carbonate, lithium carbonate, cesium carbonate, sodiumbicarbonate, potassium bicarbonate, lithium bicarbonate, cesiumbicarbonate and combinations thereof.
 10. The process according to claim9, wherein the first metal carbonate is sodium carbonate.
 11. Theprocess according to claim 1, wherein the second metal carbonate isselected from the group consisting of sodium carbonate, potassiumcarbonate, lithium carbonate, cesium carbonate, sodium bicarbonate,potassium bicarbonate, lithium bicarbonate, cesium bicarbonate andcombinations thereof.
 12. The process according to claim 11, wherein thesecond metal carbonate is potassium carbonate.
 13. The process accordingto claim 1, wherein the aprotic solvent of step c) is selected from thegroup consisting of dimethyl sulfoxide, acetonitrile, acetone,dimethylformamide, ethyl acetate, tetrahydrofuran, dichloromethane andcombinations thereof.
 14. The process according to claim 1, wherein theaprotic solvent of step c) is dimethylformamide.
 15. The processaccording to claim 1, wherein step c) comprises reacting the compound offormula IV with a R²-boronic acid, copper acetate (catalytic) and sodiumcarbonate in the presence of an amine ligand to produce the compound offormula V.
 16. The process according to claim 1, wherein the inertsolvent of step d) is methanol.
 17. The process according to claim 1,wherein the metal hydroxide is selected from the group consisting ofsodium hydroxide, potassium hydroxide, lithium hydroxide, magnesiumhydroxide, calcium hydroxide and combinations thereof.
 18. The processaccording to claim 17, wherein the metal hydroxide is sodium hydroxide.19. The process according to claim 1 further comprising the step of: e)reacting the compound of formula I with a nitration agent to produce acompound of formula VI,


20. The process according to claim 19, wherein the nitration agent isselected from the group consisting of NaNO₂/AcOH, HNO₃/H₂SO₄,N₂O₅/P₂O₅/CCl₄, HONO, EtONO₂, CH₃COONO₂ and NO₂ ⁺CF₃SO₃ ⁻ andcombinations thereof.
 21. The process according to claim 20, wherein thenitration agent is NaNO₂/AcOH.
 22. The process according to claim 19further comprising the step of: f) reacting the compound of formula VIwith an acylating agent of the formula R′—CO—W′ to produce a compound offormula VII

wherein R′ is selected from the group consisting of hydrogen, halogen,substituted or unsubstituted (C₁-C₈)alkyl, (C₃-C₈)alkenyl,(C₃-C₈)alkynyl, (C₁-C₈)alkoxy, (C₃-C₈)cycloalkyl,(C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₄-C₁₀)heterocycle,(C₄-C₁₀)heterocycle(C₁-C₈)alkyl-, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl, (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, and —X(Z¹)_(n)—Z; X is a 5-10 member heteroaryl ringhaving one nitrogen atom and optionally interrupted by 1, 2, or 3non-peroxide oxy (—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—)or amine —N(R⁹)— groups; Z is —OR³, —SR³, halo, —S(O)_(m)—NR⁴R⁵, —NR⁴R⁵,or (C₄-C₁₀)heterocycle wherein the heterocycle is optionally substitutedwith 1, 2, 3, or 4 substituents independently selected from halo, cyano,nitro, —OR^(a), —SR^(a), (C₁-C₈)alkyl, (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl,hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,—NR^(b)R^(c), —C(O)R^(a), —COOR^(a), or —C(O)NR^(b)R^(c); each Z¹ isindependently (C₁-C₈)alkyl, (C₂-C₈)alkenyl, (C₂-C₈)alkynyl, —OR⁶, —SR⁶,halo, R⁶O(C₁-C₈)alkyl, R⁷R⁸N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR⁷R⁸,R⁷R⁸N(C₁-C₈)alkyl, —C(O)R⁶, —COOR⁶, or —C(O)NR⁷R⁸; R³ is (C₁-C₈)alkyl,(C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-,(C₅-C₁₀)heteroaryl, (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —C(O)R⁶, or—C(O)NR⁷R⁸; R⁴ and R⁵ are independently hydrogen, (C₁-C₈)alkyl,(C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy, (C₃-C₈)cycloalkyl,(C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₆-C₁₈)polycycloalkyl,(C₆-C₁₈)polycycloalkyl(C₁-C₈)alkyl-, (C₃-C₁₀)heterocycle,(C₃-C₁₀)heterocycle(C₁-C₈)alkyl —NR⁷R⁸, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl,(C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —(C₂-C₄—Y)_(q)—(CH₂)₂₋₄—X¹, —C(O)R⁶,—CO₂R⁶, —C(O)NR⁷R⁸, or —S(O)₂—NR⁷R⁸; or R⁴ and R⁵ together with theatoms to which they are attached form a saturated or partiallyunsaturated, mono-, bicyclic- or aromatic ring having 3, 4, 5, 6, 7, or8, ring atoms and optionally comprising 1, 2, 3, or 4 heteroatomsselected from non-peroxide oxy (—O—), thio (—S—), sulfinyl (—SO—),sulfonyl (—S(O)₂—) and amine —N(R⁹)— in the ring, wherein the ring isoptionally substituted with 1, 2, 3, or 4 substituents independentlyselected from halo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl,—O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a), —COOR^(a), and—C(O)NR^(b)R^(c); X¹ is —OR⁶, —C(O)R⁶, —CO₂R⁶, or —NR⁷R⁸; and Y is oxy(—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) or amine —N(R⁹)—;wherein the alkyl, alkenyl, cycloalkyl, alkynyl, aryl, heterocycle, orheteroaryl groups of R′, R², R³, R⁴ and R⁵ groups are optionallysubstituted with one or more substituents independently selected fromhalo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl,hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,—NR^(b)R^(c), —C(O)R^(a), —COOR^(a), or —C(O)NR^(b)R^(c); wherein R⁶ ishydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, (C₃-C₁₀)heterocycle, (C₃-C₁₀)heterocycle(C₁-C₈)alkyl-,(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)heteroaryl, or(C₄-C₁₀)heteroaryl(C₁-C₈)alkyl-; wherein the heterocycle, heteroaryl oraryl are optionally substituted with 1, 2, 3, or 4 substituentsindependently selected from halo, cyano, nitro, —OR^(a), SR^(a),(C₆-C₁₀)aryl —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a),—COOR^(a), or —C(O)NR^(b)R^(c); wherein R⁷, R⁸ and R⁹ are independentlyhydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, (C₃-C₁₀)hetero cycle, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)heteroaryl; —COOR^(a), —C(O)R^(a), or—C(O)NR^(b)R^(c) wherein the heterocycle, heteroaryl or aryl areoptionally substituted with 1, 2, 3, or 4 substituents independentlyselected from halo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl,—O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a), —COOR^(a), orC(O)NR^(b)R^(c); or R⁷ and R⁸ together with the atoms to which they areattached form a saturated or partially unsaturated, mono-, bicyclic- oraromatic ring having 3, 4, 5, 6, 7, or 8, ring atoms optionally ringhaving from 4 to eight ring atoms and optionally comprising 1, 2, 3, or4 heteroatoms selected from non-peroxide oxy (—O—), thio (—S—), sulfinyl(—SO—), sulfonyl (—S(O)₂—) or amine —N(R^(b))— in the ring; R^(a) ishydrogen, or (C₁-C₆)alkyl; R^(b) and R^(c) are each independentlyhydrogen, (C₁-C₆)alkyl, (C₁-C₆)alkoxy, (C₃-C₈)cycloalkyl,(C₁-C₆)alkylthio, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl-, heteroaryl,or heteroaryl(C₁-C₆)alkyl-; or R^(b) and R^(c) together with thenitrogen to which they are attached, form a pyrrolidyl, piperidyl,piperazinyl, azepinyl, diazepinyl, morpholinyl, or thiomorpholinyl ring;W′ is a leaving group; where n is 0, 1, 2, 3, 4, 5, 6, 7, or 8; m is 1,or 2; and q is 1, 2, 3, or
 4. 23. The process according to claim 22wherein W′ is a halogen.
 24. The process according to claim 22 furthercomprising the step of: g) reacting the compound of formula VII with areducing agent and an aprotic solvent to produce a xanthine of formulaVIII


25. The process according to claim 24, wherein the reducing agent ofstep g) is hydrogen and palladium on carbon.
 26. The process accordingto claim 25, wherein the reducing agent of step g) is sodium dithionite.27. The process according to claim 26, wherein step g) further comprisesan aprotic solvent selected from the group consisting of dimethylsulfoxide, acetonitrile, acetone, dimethylformamide, ethyl acetate,tetrahydrofurn, dichloromethane and combinations thereof.
 28. Theprocess according to claim 27, wherein the aprotic solvent is dimethylsulfoxide.
 29. The process according to claim 19, further comprising thestep of: h) reacting the compound of formula VI with a reducing agent toproduce the compound of formula XIV.


30. The process according to claim 29, wherein the reducing agent ofstep h) is hydrogen and palladium on carbon.
 31. The process accordingto claim 29, wherein the reducing agent of step g) is sodium dithionite.32. The process according to claim 29, further comprising the step of:i) reacting the compound of formula XIV with a first acylating agent ofthe formula R′—CO—W′ to produce the compound of formula XV.

wherein R′ is selected from the group consisting of hydrogen, halogen,substituted or unsubstituted (C₁-C₈)alkyl, (C₃-C₈)alkenyl,(C₃-C₈)alkynyl, (C₁-C₈)alkoxy, (C₃-C₈)cycloalkyl,(C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₄-C₁₀)heterocycle,(C₄-C₁₀)heterocycle(C₁-C₈)alkyl-, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl, (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, and —X(Z¹)_(n)—Z; X is a 5-10 member heteroaryl ringhaving one nitrogen atom and optionally interrupted by 1, 2, or 3non-peroxide oxy (—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—)or amine —N(R⁹)— groups; Z is —OR³, SR³, halo, —S(O)_(m)—NR⁴R⁵, NR⁴R⁵,or (C₄-C₁₀)heterocycle wherein the heterocycle is optionally substitutedwith 1, 2, 3, or 4 substituents independently selected from halo, cyano,nitro, —OR^(a), SR^(a), (C₁-C₈)alkyl, (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl,hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,—NR^(b)R^(c), —C(O)R^(a), —COOR^(a), or —C(O)NR^(b)R^(c); each Z¹ isindependently (C₁-C₈)alkyl, (C₂-C₈)alkenyl, (C₂-C₈)alkynyl, —OR⁶, —SR⁶,halo, R⁶O(C₁-C₈)alkyl, R⁷R⁸N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR⁷R⁸,R⁷R⁸N(C₁-C₈)alkyl, —C(O)R⁶, —COOR⁶, or —C(O)NR⁷R⁸; R³ is (C₁-C₈)alkyl,(C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-,(C₅-C₁₀)heteroaryl, (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —C(O)R⁶, or—C(O)NR⁷R⁸; R⁴ and R⁵ are independently hydrogen, (C₁-C₈)alkyl,(C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy, (C₃-C₈)cycloalkyl,(C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₆-C₁₈)polycycloalkyl,(C₆-C₁₈)polycycloalkyl(C₁-C₈)alkyl-, (C₃-C₁₀)heterocycle,(C₃-C₁₀)heterocycle(C₁-C₈)alkyl —NR⁷R⁸, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl,(C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —(C₂-C₄—Y)_(q)—(CH₂)₂₋₄—X¹, —C(O)R⁶,—CO₂R⁶, —C(O)NR⁷R⁸, or —S(O)₂—NR⁷R⁸; or R⁴ and R⁵ together with theatoms to which they are attached form a saturated or partiallyunsaturated, mono-, bicyclic- or aromatic ring having 3, 4, 5, 6, 7, or8, ring atoms and optionally comprising 1, 2, 3, or 4 heteroatomsselected from non-peroxide oxy (—O—), thio (—S—), sulfinyl (—SO—),sulfonyl (—S(O)₂—) and amine —N(R⁹)— in the ring, wherein the ring isoptionally substituted with 1, 2, 3, or 4 substituents independentlyselected from halo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl,—O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a), —COOR^(a), and—C(O)NR^(b)R^(c); X¹ is —OR⁶, —C(O)R⁶, —CO₂R⁶, or —NR⁷R⁸; and Y is oxy(—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) or amine —N(R⁹)—;wherein the alkyl, alkenyl, cycloalkyl, alkynyl, aryl, heterocycle, orheteroaryl groups of R¹, R², R³, R⁴ and R⁵ groups are optionallysubstituted with one or more substituents independently selected fromhalo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl,hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,—NR^(b)R^(c), —C(O)R^(a), —COOR^(a), or —C(O)NR^(b)R^(c); wherein R⁶ ishydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, (C₃-C₁₀)heterocycle, (C₃-C₁₀)heterocycle(C₁-C₈)alkyl-,(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)heteroaryl, or(C₄-C₁₀)heteroaryl(C₁-C₈)alkyl-; wherein the heterocycle, heteroaryl oraryl are optionally substituted with 1, 2, 3, or 4 substituentsindependently selected from halo, cyano, nitro, —OR^(a), SR^(a),(C₆-C₁₀)aryl —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a),—COOR^(a), or —C(O)NR^(b)R^(c); wherein R⁷, R⁸ and R⁹ are independentlyhydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, (C₃-C₁₀)hetero cycle, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)heteroaryl; —COOR^(a), —C(O)R^(a), or—C(O)NR^(b)R^(c) wherein the heterocycle, heteroaryl or aryl areoptionally substituted with 1, 2, 3, or 4 substituents independentlyselected from halo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl,—O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a), —COOR^(a), orC(O)NR^(b)R^(c); or R⁷ and R⁸ together with the atoms to which they areattached form a saturated or partially unsaturated, mono-, bicyclic- oraromatic ring having 3, 4, 5, 6, 7, or 8, ring atoms optionally ringhaving from 4 to eight ring atoms and optionally comprising 1, 2, 3, or4 heteroatoms selected from non-peroxide oxy (—O—), thio (—S—), sulfinyl(—SO—), sulfonyl (—S(O)₂—) or amine —N(R^(b))— in the ring; R^(a) ishydrogen, or (C₁-C₆)alkyl; R^(b) and R^(c) are each independentlyhydrogen, (C₁-C₆)alkyl, (C₁-C₆)alkoxy, (C₃-C₈)cycloalkyl,(C₁-C₆)alkylthio, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl-, heteroaryl,or heteroaryl(C₁-C₆)alkyl-; or R^(b) and R^(c) together with thenitrogen to which they are attached, form a pyrrolidyl, piperidyl,piperazinyl, azepinyl, diazepinyl, morpholinyl, or thiomorpholinyl ring;W′ is a leaving group; where n is 0, 1, 2, 3, 4, 5, 6, 7, or 8; m is 1,or 2; and q is 1, 2, 3, or
 4. 33. The process according to claim 32,wherein R′ is selected from the group consisting of:


34. The process according to claim 32, further comprising the step of:j) reacting the compound of formula XV with a metal hydroxide to producethe compound of formula VIII.


35. The process according to claim 34, wherein the metal hydroxide isselected from the group consisting of sodium hydroxide, potassiumhydroxide, lithium hydroxide, magnesium hydroxide, calcium hydroxide andcombinations thereof.
 36. The process according to claim 34, wherein themetal hydroxide is sodium hydroxide.
 37. The process according to claim34, further comprising the step of: k) reacting the compound of formulaVIII with a second acylating agent of the formula R″—CO—W″ to producethe compound of formula XVI.

wherein R″ is selected from the group consisting of hydrogen, halogen,substituted or unsubstituted (C₁-C₈)alkyl, (C₃-C₈)alkenyl,(C₃-C₈)alkynyl, (C₁-C₈)alkoxy, (C₃-C₈)cycloalkyl,(C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₄-C₁₀)heterocycle,(C₄-C₁₀)heterocycle(C₁-C₈)alkyl-, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl, (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, and —X(Z¹)_(n)—Z; X is a 5-10 member heteroaryl ringhaving one nitrogen atom and optionally interrupted by 1, 2, or 3non-peroxide oxy (—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—)or amine —N(R⁹)— groups; Z is —OR³, —SR³, halo, —S(O)_(m)—NR⁴R⁵, —NR⁴R⁵,or (C₄-C₁₀)heterocycle wherein the heterocycle is optionally substitutedwith 1, 2, 3, or 4 substituents independently selected from halo, cyano,nitro, —OR^(a), —SR^(a), (C₁-C₈)alkyl, (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl,hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,—NR^(b)R^(c), —C(O)R^(a), —COOR^(a), or —C(O)NR^(b)R^(c); each Z¹ isindependently (C₁-C₈)alkyl, (C₂-C₈)alkenyl, (C₂-C₈)alkynyl, —OR⁶, —SR⁶,halo, R⁶O(C₁-C₈)alkyl, R⁷R⁸N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR⁷R⁸,R⁷R⁸N(C₁-C₈)alkyl, —C(O)R⁶, —COOR⁶, or —C(O)NR⁷R⁸; R³ is (C₁-C₈)alkyl,(C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-,(C₅-C₁₀)heteroaryl, (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —C(O)R⁶, or—C(O)NR⁷R⁸; R⁴ and R⁵ are independently hydrogen, (C₁-C₈)alkyl,(C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy, (C₃-C₈)cycloalkyl,(C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₆-C₁₈)polycycloalkyl,(C₆-C₁₈)polycycloalkyl(C₁-C₈)alkyl-, (C₃-C₁₀)heterocycle,(C₃-C₁₀)heterocycle(C₁-C₈)alkyl —NR⁷R⁸, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl,(C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —(C₂-C₄—Y)_(q)—(CH₂)₂₋₄—X¹, —C(O)R⁶,—CO₂R⁶, —C(O)NR⁷R⁸, or —S(O)₂—NR⁷R⁸; or R⁴ and R⁵ together with theatoms to which they are attached form a saturated or partiallyunsaturated, mono-, bicyclic- or aromatic ring having 3, 4, 5, 6, 7, or8, ring atoms and optionally comprising 1, 2, 3, or 4 heteroatomsselected from non-peroxide oxy (—O—), thio (—S—), sulfinyl (—SO—),sulfonyl (—S(O)₂—) and amine —N(R⁹)— in the ring, wherein the ring isoptionally substituted with 1, 2, 3, or 4 substituents independentlyselected from halo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl,—O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a), —COOR^(a), and—C(O)NR^(b)R^(c); X¹ is —OR⁶, —C(O)R⁶, —CO₂R⁶, or —NR⁷R⁸; and Y is oxy(—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) or amine —N(R⁹)—;wherein the alkyl, alkenyl, cycloalkyl, alkynyl, aryl, heterocycle, orheteroaryl groups of R¹, R², R³, R⁴ and R⁵ groups are optionallysubstituted with one or more substituents independently selected fromhalo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl,hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,—NR^(b)R^(c), —C(O)R^(a), —COOR^(a), or —C(O)NR^(b)R^(c); wherein R⁶ ishydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, (C₃-C₁₀)heterocycle, (C₃-C₁₀)heterocycle(C₁-C₈)alkyl-,(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)heteroaryl, or(C₄-C₁₀)heteroaryl(C₁-C₈)alkyl-; wherein the heterocycle, heteroaryl oraryl are optionally substituted with 1, 2, 3, or 4 substituentsindependently selected from halo, cyano, nitro, —OR^(a), SR^(a),(C₆-C₁₀)aryl O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a),—COOR^(a), or —C(O)NR^(b)R^(c); wherein R⁷, R⁸ and R⁹ are independentlyhydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, (C₃-C₁₀)hetero cycle, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)heteroaryl; —COOR^(a), —C(O)R^(a), or—C(O)NR^(b)R^(c) wherein the heterocycle, heteroaryl or aryl areoptionally substituted with 1, 2, 3, or 4 substituents independentlyselected from halo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl,—O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a), —COOR^(a), orC(O)NR^(b)R^(c); or R⁷ and R⁸ together with the atoms to which they areattached form a saturated or partially unsaturated, mono-, bicyclic- oraromatic ring having 3, 4, 5, 6, 7, or 8, ring atoms optionally ringhaving from 4 to eight ring atoms and optionally comprising 1, 2, 3, or4 heteroatoms selected from non-peroxide oxy (—O—), thio (—S—), sulfinyl(—SO—), sulfonyl (—S(O)₂—) or amine —N(R^(b))— in the ring; R^(a) ishydrogen, or (C₁-C₆)alkyl; R^(b) and R^(c) are each independentlyhydrogen, (C₁-C₆)alkyl, (C₁-C₆)alkoxy, (C₃-C₈)cycloalkyl,(C₁-C₆)alkylthio, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl-, heteroaryl,or heteroaryl(C₁-C₆)alkyl-; or R^(b) and R^(c) together with thenitrogen to which they are attached, form a pyrrolidyl, piperidyl,piperazinyl, azepinyl, diazepinyl, morpholinyl, or thiomorpholinyl ring;W″ is a leaving group; where n is 0, 1, 2, 3, 4, 5, 6, 7, or 8; m is 1,or 2; and q is 1, 2, 3, or
 4. 38. The process according to claim 37,wherein R″ is selected from the group consisting of:


39. The process according to claim 37, wherein R′ and R″ are selectedfrom the following pairs:


40. A process for preparing a xanthine compound of formula IX:

wherein: R¹ and R² are independently hydrogen, (C₁-C₈)alkyl,(C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy, (C₃-C₈)cycloalkyl,(C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₄-C₁₀)heterocycle,(C₄-C₁₀)heterocycle(C₁-C₈)alkyl-, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl, or(C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-; R′ is selected from the groupconsisting of hydrogen, halogen, substituted or unsubstituted(C₁-C₈)alkyl, (C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy,(C₃-C₈)cycloalkyl, (C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₄-C₁₀)heterocycle,(C₄-C₁₀)heterocycle(C₁-C₈)alkyl-, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl,(C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, and —X(Z¹)_(n)—Z; X is a 5-10 memberheteroaryl ring having one nitrogen atom and optionally interrupted by1, 2, or 3 non-peroxide oxy (—O—), thio (—S—), sulfinyl (—SO—), sulfonyl(—S(O)₂—) or amine —N(R⁹)— groups; Z is —OR³, —SR³, halo,—S(O)_(m)—NR⁴R⁵, —NR⁴R⁵, or (C₄-C₁₀)heterocycle wherein the heterocycleis optionally substituted with 1, 2, 3, or 4 substituents independentlyselected from halo, cyano, nitro, —OR^(a), —SR^(a), (C₁-C₈)alkyl,(C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a),—COOR^(a), or —C(O)NR^(b)R^(c); each Z¹ is independently (C₁-C₈)alkyl,(C₂-C₈)alkenyl, (C₂-C₈)alkynyl, —OR⁶, SR⁶, halo, R⁶O(C₁-C₈)alkyl,R⁷R⁸N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR⁷R⁸, R⁷R⁸N(C₁-C₈)alkyl, —C(O)R⁶,—COOR⁶, or —C(O)NR⁷R⁸; R³ is (C₁-C₈)alkyl, (C₃-C₈)alkenyl,(C₃-C₈)alkynyl, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-,(C₅-C₁₀)heteroaryl, (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —C(O)R⁶, or—C(O)NR⁷R⁸; R⁴ and R⁵ are independently hydrogen, (C₁-C₈)alkyl,(C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy, (C₃-C₈)cycloalkyl,(C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₆-C₁₈)polycycloalkyl,(C₆-C₁₈)polycycloalkyl(C₁-C₈)alkyl-, (C₃-C₁₀)heterocycle,(C₃-C₁₀)heterocycle(C₁-C₈)alkyl —NR⁷R⁸, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl,(C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —(C₂-C₄—Y)_(q)—(CH₂)₂₋₄—X¹, C(O)R⁶,—CO₂R⁶, —C(O)NR⁷R⁸, or —S(O)₂—NR⁷R⁸; or R⁴ and R⁵ together with theatoms to which they are attached form a saturated or partiallyunsaturated, mono-, bicyclic- or aromatic ring having 3, 4, 5, 6, 7, or8, ring atoms and optionally comprising 1, 2, 3, or 4 heteroatomsselected from non-peroxide oxy (—O—), thio (—S—), sulfinyl (—SO—),sulfonyl (—S(O)₂—) and amine —N(R⁹)— in the ring, wherein the ring isoptionally substituted with 1, 2, 3, or 4 substituents independentlyselected from halo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl,—O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a), —COOR^(a), or—C(O)NR^(b)R^(c); X¹ is —OR⁶, —C(O)R⁶, —CO₂R⁶, or —NR⁷R⁸; and Y is oxy(—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) or amine —N(R⁹)—;wherein the alkyl, alkenyl, cycloalkyl, alkynyl, aryl, heterocycle, orheteroaryl groups of R¹, R², R³, R⁴ and R⁵ groups are optionallysubstituted with one or more substituents independently selected fromhalo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl,hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,—NR^(b)R^(c), —C(O)R^(a), —COOR^(a), or —C(O)NR^(b)R^(c); wherein R⁶ ishydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, (C₃-C₁₀)heterocycle, (C₃-C₁₀)heterocycle(C₁-C₈)alkyl-,(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)heteroaryl, or(C₄-C₁₀)heteroaryl(C₁-C₈)alkyl-; wherein the heterocycle, heteroaryl oraryl are optionally substituted with 1, 2, 3, or 4 substituentsindependently selected from halo, cyano, nitro, —OR^(a), SR^(a),(C₆-C₁₀)aryl —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c), C(O)R^(a),—COOR^(a), or —C(O)NR^(b)R^(c); wherein R⁷, R⁸ and R⁹ are independentlyhydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, (C₃-C₁₀)hetero cycle, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)heteroaryl; —COOR^(a), —C(O)R^(a), or—C(O)NR^(b)R^(c) wherein the heterocycle, heteroaryl or aryl areoptionally substituted with 1, 2, 3, or 4 substituents independentlyselected from halo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl,—O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a), —COOR^(a), orC(O)NR^(b)R^(c); or R⁷ and R⁸ together with the atoms to which they areattached form a saturated or partially unsaturated, mono-, bicyclic- oraromatic ring having 3, 4, 5, 6, 7, or 8, ring atoms optionally ringhaving from 4 to eight ring atoms and optionally comprising 1, 2, 3, or4 heteroatoms selected from non-peroxide oxy (—O—), thio (—S—), sulfinyl(—SO—), sulfonyl (—S(O)₂—) or amine —N(R^(b))— in the ring; R^(a) ishydrogen, or (C₁-C₆)alkyl; R^(b) and R^(c) are each independentlyhydrogen, (C₁-C₆)alkyl, (C₁-C₆)alkoxy, (C₃-C₈)cycloalkyl,(C₁-C₆)alkylthio, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl-, heteroaryl,or heteroaryl(C₁-C₆)alkyl-; or R^(b) and R^(c) together with thenitrogen to which they are attached, form a pyrrolidyl, piperidyl,piperazinyl, azepinyl, diazepinyl, morpholinyl, or thiomorpholinyl ring;where n is 0, 1, 2, 3, 4, 5, 6, 7, or 8; m is 1, or 2; and q is 1, 2, 3,or 4; the process comprising: a) reacting a monosubstituted urea offormula II

with 3-amino-3-ethoxy-acrylate in the presence of an alkoxide to producean aminouracil of formula IIIb,

b) reacting the aminouracil of formula Mb with a nitration agent toproduce a compound of formula X,

c) reacting the compound of formula X with a reducing agent to produce acompound of formula XI, and,

d) reacting the compound of formula XI with a first acylating agent ofthe formula R′—CO—W′ to produce a compound of formula XII

wherein W′ is a leaving group, e) reacting the compound of formula XIIwith a R²-halide, metal carbonate, and an aprotic solvent to produce acompound of formula XIII, and,

f) reacting the compound of formula XIII with an inert solvent and ametal hydroxide to produce the xanthine compound of formula IX.
 41. Theprocess according to claim 40, wherein the alkoxide is a metal alkoxideselected from the group consisting of potassium tert-butoxide, sodiumethoxide, potassium ethoxide, calcium ethoxide, sodium tert-butoxide andcombinations thereof.
 42. The process according to 41, wherein the metalalkoxide is sodium ethoxide.
 43. The process according to claim 40,wherein the nitration agent is selected from the group consisting ofNaNO₂/AcOH, HNO₃/H₂SO₄, N₂O₅/P₂O₅/CCl₄, HONO, EtONO₂, CH₃COONO₂, NO₂⁺CF₃SO₃ ⁻ and combinations thereof.
 44. The process according to claim43, wherein the nitration agent is NaNO₂/AcOH.
 45. The process accordingto claim 40, wherein the reducing agent of step c) is hydrogen andpalladium on carbon.
 46. The process according to claim 40, wherein thereducing agent of step c) is sodium dithionite.
 47. The processaccording to claim 46, wherein step c) further comprises an aproticsolvent selected from the group consisting of dimethyl sulfoxide,acetonitrile, acetone, dimethylformamide, ethyl acetate, tetrahydrofurn,dichloromethane and combinations thereof.
 48. The process according toclaim 47, wherein the aprotic solvent of step c) is dimethyl sulfoxide.49. The process according to claim 40, wherein the metal carbonate isselected from the group consisting of sodium carbonate, potassiumcarbonate, lithium carbonate, cesium carbonate, sodium bicarbonate,potassium bicarbonate, lithium bicarbonate, cesium bicarbonate andcombinations thereof. 50 The process according to claim 49, wherein themetal carbonate is potassium carbonate.
 51. The process according toclaim 40, wherein the aprotic solvent of step e) is selected from thegroup consisting of dimethyl sulfoxide, acetonitrile, acetone,dimethylformamide, ethyl acetate, tetrahydrofuran, dichloromethane andcombinations thereof.
 52. The process according to claim 51, wherein theaprotic solvent of step e) is dimethylformamide.
 53. The processaccording to claim 40, wherein the inert solvent of step f) is selectedfrom the group consisting of methanol, ethanol, isopropanol, andcombinations thereof.
 54. The process according to claim 53, wherein theinert solvent of step f) is methanol.
 55. The process according to claim40, wherein the metal hydroxide is selected from the group consisting ofsodium hydroxide, potassium hydroxide, lithium hydroxide, magnesiumhydroxide, calcium hydroxide and combinations thereof.
 56. The processaccording to claim 55, wherein the metal hydroxide is sodium hydroxide.57. The process according to claim 40, wherein R′ is selected from thegroup consisting of:


58. The process according to claim 40, further comprising the step of:g) reacting the compound of formula IX with a second acylating agent ofthe formula R″—CO—W″ to produce the compound of formula XVII,

wherein R″ is selected from the group consisting of hydrogen, halogen,substituted or unsubstituted (C₁-C₈)alkyl, (C₃-C₈)alkenyl,(C₃-C₈)alkynyl, (C₁-C₈)alkoxy, (C₃-C₈)cycloalkyl,(C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₄-C₁₀)heterocycle,(C₄-C₁₀)heterocycle(C₁-C₈)alkyl-, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl, (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, and —X(Z¹)_(n)—Z; X is a 5-10 member heteroaryl ringhaving one nitrogen atom and optionally interrupted by 1, 2, or 3non-peroxide oxy (—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—)or amine —N(R⁹)— groups; Z is —OR³, —SR³, halo, —S(O)_(m)—NR⁴R⁵, —NR⁴R⁵,or (C₄-C₁₀)heterocycle wherein the heterocycle is optionally substitutedwith 1, 2, 3, or 4 substituents independently selected from halo, cyano,nitro, —OR^(a), SR^(a), (C₁-C₈)alkyl, (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl,hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,—NR^(b)R^(c), —C(O)R^(a), —COOR^(a), or —C(O)NR^(b)R^(c); each Z¹ isindependently (C₁-C₈)alkyl, (C₂-C₈)alkenyl, (C₂-C₈)alkynyl, —OR⁶, —SR⁶,halo, R⁶⁰ (C₁-C₈)alkyl, R⁷R⁸N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR⁷R⁸,R⁷R⁸N(C₁-C₈)alkyl, —C(O)R⁶, —COOR⁶, or —C(O)NR⁷R⁸; R³ is (C₁-C₈)alkyl,(C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-,(C₅-C₁₀)heteroaryl, (C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —C(O)R⁶, or—C(O)NR⁷R⁸; R⁴ and R⁵ are independently hydrogen, (C₁-C₈)alkyl,(C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₁-C₈)alkoxy, (C₃-C₈)cycloalkyl,(C₃-C₈)cycloalkyl(C₁-C₈)alkyl-, (C₆-C₁₈)polycycloalkyl,(C₆-C₁₈)polycycloalkyl(C₁-C₈)alkyl-, (C₃-C₁₀)heterocycle,(C₃-C₁₀)heterocycle(C₁-C₈)alkyl —NR⁷R⁸, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₅-C₁₀)heteroaryl,(C₅-C₁₀)heteroaryl(C₁-C₈)alkyl-, —(C₂-C₄—Y)_(q)—(CH₂)₂₋₄—X¹, —C(O)R⁶,—CO₂R⁶, —C(O)NR⁷R⁸, or —S(O)₂—NR⁷R⁸; or R⁴ and R⁵ together with theatoms to which they are attached form a saturated or partiallyunsaturated, mono-, bicyclic- or aromatic ring having 3, 4, 5, 6, 7, or8, ring atoms and optionally comprising 1, 2, 3, or 4 heteroatomsselected from non-peroxide oxy (—O—), thio (—S—), sulfinyl (—SO—),sulfonyl (—S(O)₂—) and amine —N(R⁹)— in the ring, wherein the ring isoptionally substituted with 1, 2, 3, or 4 substituents independentlyselected from halo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl,—O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a), —COOR^(a), and—C(O)NR^(b)R^(c); X¹ is —OR⁶, —C(O)R⁶, —CO₂R⁶, or —NR⁷R⁸; and Y is oxy(—O—), thio (—S—), sulfinyl (—SO—), sulfonyl (—S(O)₂—) or amine —N(R⁹)—;wherein the alkyl, alkenyl, cycloalkyl, alkynyl, aryl, heterocycle, orheteroaryl groups of R¹, R², R³, R⁴ and R⁵ groups are optionallysubstituted with one or more substituents independently selected fromhalo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl, —O(C₆-C₁₀)aryl,hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl,—NR^(b)R^(c), —C(O)R^(a), —COOR^(a), or —C(O)NR^(b)R^(c); wherein R⁶ ishydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, (C₃-C₁₀)heterocycle, (C₃-C₁₀)heterocycle(C₁-C₈)alkyl-,(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)heteroaryl, or(C₄-C₁₀)heteroaryl(C₁-C₈)alkyl-; wherein the heterocycle, heteroaryl oraryl are optionally substituted with 1, 2, 3, or 4 substituentsindependently selected from halo, cyano, nitro, —OR^(a), SR^(a),(C₆-C₁₀)aryl —O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl,R^(b)R^(c)N(C₁-C₈)alkyl, halo(C₁-C₈)alkyl, —NR^(b)R^(c), C(O)R^(a),—COOR^(a), or —C(O)NR^(b)R^(c); wherein R⁷, R⁸ and R⁹ are independentlyhydrogen, (C₁-C₈)alkyl, R^(a)O(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, (C₃-C₁₀)hetero cycle, (C₆-C₁₀)aryl,(C₆-C₁₀)aryl(C₁-C₈)alkyl-, (C₄-C₁₀)heteroaryl; —COOR^(a), —C(O)R^(a), or—C(O)NR^(b)R^(c) wherein the heterocycle, heteroaryl or aryl areoptionally substituted with 1, 2, 3, or 4 substituents independentlyselected from halo, cyano, nitro, —OR^(a), —SR^(a), (C₆-C₁₀)aryl,—O(C₆-C₁₀)aryl, hydroxy(C₁-C₈)alkyl, R^(b)R^(c)N(C₁-C₈)alkyl,halo(C₁-C₈)alkyl, —NR^(b)R^(c), —C(O)R^(a), —COOR^(a), orC(O)NR^(b)R^(c); or R⁷ and R⁸ together with the atoms to which they areattached form a saturated or partially unsaturated, mono-, bicyclic- oraromatic ring having 3, 4, 5, 6, 7, or 8, ring atoms optionally ringhaving from 4 to eight ring atoms and optionally comprising 1, 2, 3, or4 heteroatoms selected from non-peroxide oxy (—O—), thio (—S—), sulfinyl(—SO—), sulfonyl (—S(O)₂—) or amine —N(R^(b))— in the ring; R^(a) ishydrogen, or (C₁-C₆)alkyl; R^(b) and R^(c) are each independentlyhydrogen, (C₁-C₆)alkyl, (C₁-C₆)alkoxy, (C₃-C₈)cycloalkyl,(C₁-C₆)alkylthio, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl-, heteroaryl,or heteroaryl(C₁-C₆)alkyl-; or R^(b) and R^(c) together with thenitrogen to which they are attached, form a pyrrolidyl, piperidyl,piperazinyl, azepinyl, diazepinyl, morpholinyl, or thiomorpholinyl ring;W″ is a leaving group, and where n is 0, 1, 2, 3, 4, 5, 6, 7, or 8; m is1, or 2; and q is 1, 2, 3, or
 4. 59. The process according to claim 58wherein R″ is selected from the group consisting of:


60. The process according to claim 58, wherein R′ and R″ are selectedfrom the following pairs: